| 16.10.2021 | 19:00 | TVA Hürth Volleyball | DJK Delbrück | 0:3 (19:25, 24:26, 12:25) |
| 16.10.2021 | 19:00 | PTSV Aachen | Rhein-Sieg Volleys Much & Buisdorf | 3:0 (25:16, 27:25, 25:18) |
| 16.10.2021 | 20:00 | TSV Giesen GRIZZLYS II | SF Aligse | 0:3 (20:25, 29:31, 22:25) |
| 16.10.2021 | 20:00 | Tecklenburger Land Volleys | TV Hörde | 3:1 (30:28, 19:25, 25:21, 25:23) |
| 17.10.2021 | 14:30 | FCJ Köln | VC 73 Freudenberg | 3:0 (25:17, 25:20, 25:13) |
| 17.10.2021 | 16:00 | TV Hörde | TSC Gievenbeck | 1:3 (23:25, 25:23, 20:25, 23:25) |
| 23.10.2021 | 18:00 | DJK Delbrück | PTSV Aachen | 1:3 (13:25, 18:25, 25:20, 21:25) |
| 23.10.2021 | 19:00 | Rhein-Sieg Volleys Much & Buisdorf | FCJ Köln | 1:3 (23:25, 25:18, 24:26, 23:25) |
| 23.10.2021 | 19:30 | VC 73 Freudenberg | TSV Giesen GRIZZLYS II | 2:3 (20:25, 25:23, 25:23, 19:25, 12:15) |
| 23.10.2021 | 19:30 | TV Hörde | TVA Hürth Volleyball | 3:2 (26:24, 25:23, 23:25, 17:25, 15:13) |
| 23.10.2021 | 20:00 | SF Aligse | Tecklenburger Land Volleys | 3:2 (25:17, 25:19, 14:25, 17:25, 15:13) |
| 24.10.2021 | 16:00 | TSC Gievenbeck | DJK Delbrück | 3:2 (21:25, 22:25, 25:23, 26:24, 18:16) |
| 30.10.2021 | 19:00 | TVA Hürth Volleyball | PTSV Aachen | 1:3 (25:21, 23:25, 15:25, 22:25) |
| 30.10.2021 | 19:00 | FCJ Köln | DJK Delbrück | 3:2 (29:27, 25:23, 23:25, 18:25, 15:11) |
| 30.10.2021 | 19:30 | TV Hörde | SF Aligse | 1:3 (15:25, 31:29, 13:25, 15:25) |
| 30.10.2021 | 20:00 | TSV Giesen GRIZZLYS II | Rhein-Sieg Volleys Much & Buisdorf | 3:0 (25:23, 26:24, 25:18) |
| 30.10.2021 | 20:00 | Tecklenburger Land Volleys | VC 73 Freudenberg | 3:0 (25:14, 25:18, 25:16) |
| 31.10.2021 | 16:00 | SF Aligse | TSC Gievenbeck | 3:1 (25:22, 19:25, 26:24, 25:12) |
| 05.11.2021 | 20:00 | Tecklenburger Land Volleys | TSC Gievenbeck | 2:3 (25:20, 27:29, 25:19, 17:25, 11:15) |
| 13.11.2021 | 18:00 | DJK Delbrück | TSV Giesen GRIZZLYS II | 3:1 (23:25, 25:23, 25:17, 25:22) |
| 13.11.2021 | 18:30 | TSC Gievenbeck | PTSV Aachen | 3:0 (25:20, 25:20, 25:21) |
| 13.11.2021 | 19:00 | Rhein-Sieg Volleys Much & Buisdorf | Tecklenburger Land Volleys | 3:2 (21:25, 25:19, 25:21, 18:25, 19:17) |
| 13.11.2021 | 20:00 | SF Aligse | TVA Hürth Volleyball | 3:2 (26:28, 25:21, 20:25, 25:14, 15:8) |
| 14.11.2021 | 16:00 | PTSV Aachen | FCJ Köln | 2:3 (23:25, 27:25, 18:25, 25:23, 10:15) |
| 20.11.2021 | 16:00 | SF Aligse | VC 73 Freudenberg | 3:1 (25:21, 25:12, 20:25, 25:12) |
| 20.11.2021 | 19:30 | TV Hörde | Rhein-Sieg Volleys Much & Buisdorf | 3:0 (25:13, 25:22, 25:18) |
| 20.11.2021 | 20:00 | Tecklenburger Land Volleys | DJK Delbrück | 1:3 (23:25, 26:24, 16:25, 17:25) |
| 21.11.2021 | 16:00 | TSV Giesen GRIZZLYS II | PTSV Aachen | 2:3 (22:25, 25:14, 25:23, 22:25, 11:15) |
| 21.11.2021 | 16:00 | VC 73 Freudenberg | TSC Gievenbeck | 0:3 (17:25, 14:25, 23:25) |
| 27.11.2021 | 18:00 | DJK Delbrück | TV Hörde | 3:2 (25:21, 25:23, 20:25, 22:25, 15:10) |
| 27.11.2021 | 18:30 | TSC Gievenbeck | FCJ Köln | 3:1 (22:25, 25:23, 25:21, 25:14) |
| 27.11.2021 | 19:00 | Rhein-Sieg Volleys Much & Buisdorf | SF Aligse | 3:0 (25:22, 25:20, 25:23) |
| 28.11.2021 | 17:00 | FCJ Köln | TSV Giesen GRIZZLYS II | 3:1 (20:25, 25:23, 25:17, 25:23) |
| 11.12.2021 | 16:00 | TV Hörde | PTSV Aachen | 3:2 (16:25, 14:25, 25:21, 25:23, 15:11) |
| 11.12.2021 | 19:00 | TVA Hürth Volleyball | TSV Giesen GRIZZLYS II | 3:2 (24:26, 25:23, 15:25, 25:18, 15:12) |
| 11.12.2021 | 19:30 | VC 73 Freudenberg | Rhein-Sieg Volleys Much & Buisdorf | 1:3 (19:25, 25:22, 22:25, 19:25) |
| 11.12.2021 | 20:00 | SF Aligse | DJK Delbrück | 1:3 (25:22, 21:25, 20:25, 21:25) |
| 11.12.2021 | 20:00 | Tecklenburger Land Volleys | FCJ Köln | 0:3 (23:25, 20:25, 15:25) |
| 12.12.2021 | 16:00 | Rhein-Sieg Volleys Much & Buisdorf | TSC Gievenbeck | 3:1 (20:25, 25:16, 25:20, 25:22) |
| 18.12.2021 | 17:30 | FCJ Köln | TV Hörde | 1:3 (25:23, 22:25, 21:25, 21:25) |
| 18.12.2021 | 18:00 | DJK Delbrück | VC 73 Freudenberg | 3:0 (25:14, 25:19, 25:19) |
| 18.12.2021 | 18:30 | TSC Gievenbeck | TSV Giesen GRIZZLYS II | 3:2 (25:27, 25:17, 29:31, 25:20, 15:11) |
| 18.12.2021 | 19:00 | TVA Hürth Volleyball | Rhein-Sieg Volleys Much & Buisdorf | 3:0 (25:18, 25:21, 27:25) |
| 18.12.2021 | 19:00 | PTSV Aachen | SF Aligse | 1:3 (25:23, 16:25, 24:26, 19:25) |
| 19.12.2021 | 16:00 | TSV Giesen GRIZZLYS II | Tecklenburger Land Volleys | 3:1 (25:21, 20:25, 25:21, 25:23) |
| 08.01.2022 | 19:00 | Rhein-Sieg Volleys Much & Buisdorf | DJK Delbrück | 0:3 (20:25, 30:32, 19:25) |
| 08.01.2022 | 19:30 | VC 73 Freudenberg | PTSV Aachen | 1:3 (16:25, 13:25, 25:19, 15:25) |
| 08.01.2022 | 19:30 | TV Hörde | TSV Giesen GRIZZLYS II | 3:1 (25:22, 25:19, 23:25, 25:15) |
| 08.01.2022 | 20:00 | SF Aligse | FCJ Köln | 1:3 (25:16, 18:25, 24:26, 24:26) |
| 08.01.2022 | 20:00 | Tecklenburger Land Volleys | TVA Hürth Volleyball | 3:0 (25:20, 25:17, 26:24) |
| 09.01.2022 | 16:00 | TVA Hürth Volleyball | TSC Gievenbeck | 0:3 (21:25, 17:25, 22:25) |
| 15.01.2022 | 18:00 | DJK Delbrück | TVA Hürth Volleyball | 3:0 (25:11, 25:22, 25:17) |
| 15.01.2022 | 19:00 | Rhein-Sieg Volleys Much & Buisdorf | PTSV Aachen | 1:3 (20:25, 25:21, 26:28, 19:25) |
| 15.01.2022 | 19:30 | VC 73 Freudenberg | FCJ Köln | 0:3 (30:32, 19:25, 17:25) |
| 16.01.2022 | 16:00 | TV Hörde | Tecklenburger Land Volleys | 3:0 (25:15, 25:22, 25:17) |
| 22.01.2022 | 20:00 | TSV Giesen GRIZZLYS II | VC 73 Freudenberg | 3:0 (25:17, 25:23, 25:23) |
| 29.01.2022 | 19:00 | PTSV Aachen | DJK Delbrück | 0:3 (22:25, 16:25, 23:25) |
| 30.01.2022 | 16:00 | DJK Delbrück | TSC Gievenbeck | 0:3 (27:29, 18:25, 24:26) |
| 05.02.2022 | 18:00 | DJK Delbrück | FCJ Köln | 3:2 (25:18, 23:25, 25:20, 19:25, 17:15) |
| 05.02.2022 | 18:30 | TSC Gievenbeck | SF Aligse | 3:0 (25:0, 25:0, 25:0) |
| 12.02.2022 | 19:30 | FCJ Köln | PTSV Aachen | 1:3 (22:25, 25:21, 20:25, 21:25) |
| 12.02.2022 | 20:00 | TV Hörde | VC 73 Freudenberg | 3:2 (21:25, 25:18, 10:25, 25:12, 15:9) |
| 13.02.2022 | 16:00 | TSV Giesen GRIZZLYS II | DJK Delbrück | 1:3 (23:25, 25:23, 27:29, 22:25) |
| 13.02.2022 | 16:00 | PTSV Aachen | TSC Gievenbeck | 1:3 (25:16, 23:25, 20:25, 19:25) |
| 19.02.2022 | 18:00 | DJK Delbrück | Tecklenburger Land Volleys | 3:0 (25:22, 25:18, 25:21) |
| 19.02.2022 | 18:30 | TSC Gievenbeck | VC 73 Freudenberg | 3:1 (25:15, 21:25, 25:19, 30:28) |
| 19.02.2022 | 19:00 | Rhein-Sieg Volleys Much & Buisdorf | TV Hörde | 1:3 (22:25, 19:25, 25:17, 18:25) |
| 19.02.2022 | 19:00 | PTSV Aachen | TSV Giesen GRIZZLYS II | 3:1 (23:25, 25:19, 25:17, 25:21) |
| 26.02.2022 | 19:30 | TV Hörde | DJK Delbrück | 2:3 (25:23, 25:21, 23:25, 25:27, 14:16) |
| 27.02.2022 | 14:30 | FCJ Köln | TSC Gievenbeck | 1:3 (21:25, 25:19, 21:25, 22:25) |
| 27.02.2022 | 16:00 | Tecklenburger Land Volleys | PTSV Aachen | 2:3 (25:17, 26:24, 16:25, 23:25, 10:15) |
| 05.03.2022 | 19:30 | VC 73 Freudenberg | TV Hörde | 0:3 (21:25, 22:25, 21:25) |
| 10.03.2022 | 20:30 | PTSV Aachen | TVA Hürth Volleyball | 3:1 (25:16, 16:25, 25:20, 25:20) |
| 12.03.2022 | 18:30 | TSC Gievenbeck | Rhein-Sieg Volleys Much & Buisdorf | 3:1 (25:21, 25:20, 18:25, 26:24) |
| 12.03.2022 | 19:00 | FCJ Köln | Tecklenburger Land Volleys | 3:2 (25:27, 26:28, 25:16, 25:16, 15:8) |
| 12.03.2022 | 19:00 | PTSV Aachen | TV Hörde | 2:3 (25:22, 23:25, 21:25, 25:20, 19:21) |
| 13.03.2022 | 16:00 | Rhein-Sieg Volleys Much & Buisdorf | VC 73 Freudenberg | 2:3 (23:25, 25:18, 25:23, 18:25, 16:18) |
| 13.03.2022 | 16:00 | TSV Giesen GRIZZLYS II | TVA Hürth Volleyball | 3:2 (25:20, 22:25, 26:28, 25:20, 15:12) |
| 19.03.2022 | 20:00 | Tecklenburger Land Volleys | TSV Giesen GRIZZLYS II | 3:1 (25:21, 25:18, 14:25, 31:29) |
| 26.03.2022 | 19:00 | Rhein-Sieg Volleys Much & Buisdorf | TVA Hürth Volleyball | 3:0 (25:20, 25:18, 25:16) |
| 26.03.2022 | 19:30 | VC 73 Freudenberg | DJK Delbrück | 0:3 (23:25, 21:25, 16:25) |
| 26.03.2022 | 19:30 | TV Hörde | FCJ Köln | 3:1 (25:21, 15:25, 25:22, 25:15) |
| 26.03.2022 | 20:00 | SF Aligse | PTSV Aachen | 3:2 (25:18, 20:25, 20:25, 25:21, 15:11) |
| 27.03.2022 | 16:00 | TSV Giesen GRIZZLYS II | TSC Gievenbeck | 3:1 (25:22, 25:22, 23:25, 29:27) |
| 02.04.2022 | 18:30 | TSC Gievenbeck | TV Hörde | 3:0 (25:15, 25:23, 25:21) |
| 02.04.2022 | 20:00 | FCJ Köln | Rhein-Sieg Volleys Much & Buisdorf | 1:3 (25:14, 18:25, 21:25, 18:25) |
| 02.04.2022 | 20:00 | DJK Delbrück | SF Aligse | 3:0 (25:19, 25:14, 25:17) |
| 03.04.2022 | 13:30 | TVA Hürth Volleyball | FCJ Köln | 1:3 (17:25, 24:26, 25:21, 15:25) |
| 03.04.2022 | 19:30 | TSC Gievenbeck | Tecklenburger Land Volleys | 3:0 (25:19, 25:14, 25:19) |
| 09.04.2022 | 18:00 | DJK Delbrück | Rhein-Sieg Volleys Much & Buisdorf | 3:0 (25:20, 25:15, 25:18) |
| 09.04.2022 | 18:30 | TSC Gievenbeck | TVA Hürth Volleyball | 3:0 (25:20, 25:14, 25:19) |
| 09.04.2022 | 19:00 | PTSV Aachen | VC 73 Freudenberg | 3:0 (25:19, 25:22, 25:21) |
| 09.04.2022 | 20:00 | Tecklenburger Land Volleys | SF Aligse | 2:3 (25:20, 25:20, 21:25, 16:25, 13:15) |
| 10.04.2022 | 16:00 | TVA Hürth Volleyball | Tecklenburger Land Volleys | 1:3 (20:25, 18:25, 25:23, 17:25) |
| 10.04.2022 | 16:00 | TSV Giesen GRIZZLYS II | TV Hörde | 3:2 (23:25, 25:19, 25:14, 21:25, 16:14) |
| 10.04.2022 | 16:00 | FCJ Köln | SF Aligse | 3:1 (25:22, 25:23, 20:25, 25:22) |
| 22.04.2022 | 20:00 | SF Aligse | TSV Giesen GRIZZLYS II | 0:3 (20:25, 22:25, 18:25) |
| 23.04.2022 | 19:00 | TVA Hürth Volleyball | TV Hörde | 3:0 (25:22, 25:22, 25:20) |
| 23.04.2022 | 19:30 | VC 73 Freudenberg | Tecklenburger Land Volleys | 2:3 (18:25, 25:21, 25:17, 22:25, 12:15) |
| 24.04.2022 | 16:00 | Rhein-Sieg Volleys Much & Buisdorf | TSV Giesen GRIZZLYS II | 0:3 (24:26, 23:25, 17:25) |
| 24.04.2022 | 16:00 | VC 73 Freudenberg | SF Aligse | 0:3 (23:25, 18:25, 17:25) |
| 26.04.2022 | 20:00 | TVA Hürth Volleyball | VC 73 Freudenberg | 3:0 (25:18, 25:18, 25:17) |
| 30.04.2022 | 18:00 | PTSV Aachen | Tecklenburger Land Volleys | 0:3 (21:25, 17:25, 18:25) |
| 01.05.2022 | 16:00 | FCJ Köln | TVA Hürth Volleyball | 3:2 (21:25, 25:27, 25:21, 28:26, 17:15) |
| 01.05.2022 | 18:00 | SF Aligse | Rhein-Sieg Volleys Much & Buisdorf | 3:2 (20:25, 25:20, 25:22, 28:30, 15:13) |
| 06.05.2022 | 20:00 | VC 73 Freudenberg | TVA Hürth Volleyball | 0:3 (22:25, 19:25, 22:25) |
| 07.05.2022 | 20:00 | SF Aligse | TV Hörde | 0:0 () |
| 07.05.2022 | 20:00 | Tecklenburger Land Volleys | Rhein-Sieg Volleys Much & Buisdorf | 2:3 (22:25, 15:25, 25:21, 25:23, 12:15) |
| 08.05.2022 | 16:00 | TVA Hürth Volleyball | SF Aligse | 0:0 () |
| 08.05.2022 | 16:00 | TSV Giesen GRIZZLYS II | FCJ Köln | 3:2 (22:25, 26:24, 23:25, 25:19, 15:9) |
